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1 Experiments have been performed using equilibrium dialysis to determine the binding of ["4C]prazosin to albumin, to a1-acid glycoprotein and to the plasma proteins of normal subjects and of patients with cirrhosis, chronic renal failure or chronic heart failure. 2 The influence of propranolol on prazosin binding has been studied. In addition, red blood cell to plasma partitioning of prazosin has been quantified.
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Rubin et al. (1980) studied this question.
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