Population
Renin knockout mice
Comparison
Renin gene knockout vs Normal (wild-type) mice
Design
Preclinical
Authors
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Renin dispensability for BBB integrity in mice is hypothesis-generating; should not inform human RAS therapies or practice.
Renin is essential for circulating angiotensin generation and blood pressure maintenance, but dispensable for blood-brain barrier function in mice.
Yanai et al. (2000) studied this question.
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