What question did this study set out to answer?

To evaluate whether maintenance interpersonal psychotherapy and full-dose imipramine hydrochloride prevent recurrence in patients with recurrent depression.

December 1, 1990Archives of General Psychiatry

Three-Year Outcomes for Maintenance Therapies in Recurrent Depression

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To evaluate whether maintenance interpersonal psychotherapy and full-dose imipramine hydrochloride prevent recurrence in patients with recurrent depression.
Randomized 3-year maintenance trial in 128 patients with recurrent depression who responded to short-term and continuation therapy with imipramine hydrochloride and interpersonal psychotherapy.
Utilized a five-cell study design comparing maintenance interpersonal psychotherapy alone or combined with active imipramine maintained at acute treatment dosage (mean 200 mg) versus dosage-reduction strategies.
Survival analysis demonstrated a highly significant prophylactic effect against recurrence for active imipramine hydrochloride maintained at an average dose of 200 mg.
Monthly maintenance interpersonal psychotherapy provided a modest prophylactic effect, significantly lengthening the time between depressive episodes in patients not receiving active medication.

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Implication

Randomized trial shows maintenance imipramine and psychotherapy reduce recurrence in recurrent depression, indicating full-dose pharmacotherapy provides robust long-term prophylaxis.

Cite This Study

A 1990 study studied this question.

synapsesocial.com/papers/6a7d08a0fac401f278424dda https://doi.org/10.1001/archpsyc.1990.01810240013002

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Implication

Randomized trial shows maintenance imipramine and psychotherapy reduce recurrence in recurrent depression, indicating full-dose pharmacotherapy provides robust long-term prophylaxis.

Three-Year Outcomes for Maintenance Therapies in Recurrent Depression

Key Points

Discussion

Implication

Cite This Study

Three-Year Outcomes for Maintenance Therapies in Recurrent Depression

Key Points

Discussion

Implication

Cite This Study

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