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October 1, 1992HeartOpen Access

Effect of increasing heart rate on Doppler indices of left ventricular performance in healthy men

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Why the study?

Does increasing heart rate via transoesophageal atrial pacing affect Doppler indices of left ventricular performance in healthy men?

Population

14 healthy male volunteers (10 of whom were studied)

Design

Other

Authors

TOToshiyuki OnikiTokyo Medical and Dental UniversityYHYuji HashimotoTokyo Medical and Dental UniversitySSSatoshi ShimizuKyoto Medical Center

Discussion

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Implication

May warrant heart rate adjustment in Doppler diastolic assessment; leaves open applicability beyond healthy men.

Key Points

  • To examine how progressive increases in heart rate alter Doppler measurements of left ventricular function and establish standard rate-dependent patterns in healthy individuals.
  • Conducted transoesophageal atrial pacing at rates of 70, 80, 90, and 100 ppm in 10 healthy male volunteers at a university hospital.
  • Assessed left ventricular diastolic and systolic function using Doppler measurements across each paced rate.
  • Transmitral flow velocity ratio (E/A) dropped linearly with increasing heart rate (r² = 0.806), shifting from 1.97 (0.28) at 70 ppm to 1.49 (0.21) at 80 ppm and 0.95 (0.11) at 90 ppm, corresponding to a decrease of ~0.5 per 10 beats/min.
  • The early to late velocity integral ratio (Ei/Ai) decreased from 3.03 (0.51) to 2.11 (0.24) and 1.14 (0.30) across 70, 80, and 90 ppm (r² = 0.838), while atrial filling fraction rose from 0.17 (0.03) to 0.24 (0.04) (r² = 0.343).
  • Peak aortic flow velocity and mean aortic flow acceleration showed no significant changes during pacing up to 100 ppm.

Structured PICO

Does increasing heart rate via transoesophageal atrial pacing affect Doppler indices of left ventricular performance in healthy men?

P
Population
14 healthy male volunteers (10 of whom were studied)
I
Intervention
Transoesophageal atrial pacing at rates of 70, 80, 90, and 100 ppm
O
Outcome
Doppler measurements of left ventricular function (ratio of early to late peak transmitral flow velocity [E/A], ratio of early to late time-velocity integrals of transmitral flow [Ei/Ai], atrial filling fraction [AFF], peak aortic flow velocity, mean aortic flow acceleration)surrogate

Increasing heart rate significantly decreases early-to-late transmitral flow velocity ratios, highlighting the need to correct for heart rate when assessing diastolic function.

Cite This Study

Oniki et al. (1992) studied this question.

synapsesocial.com/papers/6a7d08cba7839e36ac1cc4f5https://doi.org/10.1136/hrt.68.10.425
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