Why the study?
Does alcohol consumption trigger ventricular fibrillation in patients with Brugada syndrome?
Does alcohol consumption trigger ventricular fibrillation in patients with Brugada syndrome?
Alcohol consumption may act as a trigger for ventricular fibrillation in patients with Brugada syndrome, potentially due to its inhibitory effect on cardiac sodium channels.
Alcohol may warrant avoidance counseling in Brugada syndrome; single case leaves causal link and generalizability open.
A 37-year-old man lost consciousness suddenly due to ventricular fibrillation (VF). After cardioversion, twelve-lead ECG showed a pattern characteristic of type 1 Brugada. An implantable cardioverter defibrillator (ICD) was implanted for Brugada syndrome. In the following three years, VF occurred eight times after consumption of alcohol. Association between the Brugada syndrome and alcohol consumption has rarely been reported. Recently, it was reported that alcohol has inhibitory effect on single cardiac sodium channel gating and it may be that alcohol acted as a sodium channel blocker in this patient. Here we report a case of alcohol-induced VF in Brugada syndrome.
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Hayashi et al. (2009) studied this question.
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