Antiarrhythmic effects of flecainide

10 hospitalized patients with arrhythmias (5 with premature ventricular contractions [PVCs] >4 per min; 2 with atrial fibrillation [AF] and PVCs; 1 with PVCs and premature atrial contractions [PACs]; 2 with PACs only)

Flecainide 1 mg/kg intravenously over 5 min, with additional boluses of 0.5 mg/kg at 30- to 60-min intervals to a maximum of 5 mg/kg if needed (7 patients received 2 mg/kg, 3 patients received 1 mg/kg)

No antiarrhythmics (patients served as their own controls on days 1 and 3 of the 3-day hospitalization)

Short-term efficacy (suppression of arrhythmias) and safetysurrogate