Why the study?
The gut microbiota and its metabolites influence cardiac function in sepsis-induced cardiomyopathy, but the complex bidirectional relationship between the gut and the heart remains to be systematically elucidated.
This review highlights the bidirectional relationship between gut microbiota and cardiac function in sepsis-induced cardiomyopathy, suggesting the gut-heart axis as a potential therapeutic target.
The gut microbiota and its metabolites profoundly influence cardiac function, emerging as critical players in the pathophysiology of Sepsis-Induced Cardiomyopathy (SIC). Conversely, therapeutic interventions for SIC and the resultant cardiac alterations can reciprocally modulate gut microbial composition and function. To systematically elucidate this complex bidirectional relationship during SIC, this review delineates two key aspects: the 'forward gut-heart axis', defined as influences originating from the gut microbiota and its metabolites directed towards the cardiovascular system, and the 'reverse gut-heart axis', encompassing the reciprocal effects of cardiovascular drugs and cardiac factors on the gut microbiota. Furthermore, we explore potential therapeutic strategies for SIC centered on the targeted modulation of this intricate gut-heart interplay.
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Yu et al. (2025) studied this question.
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