Pragmatic Trials

doi:10.1056/nejmra1510059

August 3, 2016New England Journal of MedicineOpen Access

Pragmatic Trials

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Key Points

Examine the design principles, operational characteristics, and utility of pragmatic clinical trials in assessing medical interventions within real-world settings.
Assesses methodological frameworks differentiating pragmatic clinical trials from traditional explanatory randomized trials.
Evaluates key study dimensions including broad participant eligibility, routine care delivery settings, and clinically meaningful outcomes.
Highlights pragmatic trials as essential instruments for generating actionable real-world evidence across diverse clinical environments.
Demonstrates the importance of balancing operational feasibility and external validity to inform healthcare policy and routine patient care.

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Implication

Methodological review highlights the implementation of pragmatic trials in healthcare systems, indicating enhanced real-world generalizability for clinical practice.

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Cite This Study

A 2016 study studied this question.

synapsesocial.com/papers/6a7d0a17c9ada5f6b9d59de8 https://doi.org/10.1056/nejmra1510059

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Pragmatic Trials

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Pragmatic Trials

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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