Why the study?
Because the BK channel gating ring lies outside the electric field, it was unknown whether its voltage sensitivity originates from coupling to voltage-dependent channel opening, the voltage sensor, or both.
Conformational changes of RCK1 domains in BK channels are specifically coupled to voltage sensor function during allosteric modulation.
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No immediate clinical implications; leaves open targeted modulation of BK gating in cardiovascular disease.
Miranda et al. (2018) studied this question.
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