Why the study?
Although DOACs became available to prevent cardioembolic stroke caused by AF, trends in cardioembolic stroke following their introduction were unclear.
While the introduction of DOACs has decreased the overall proportion of cardioembolic strokes, a significant number of breakthrough strokes occur due to inappropriate DOAC dosing or non-adherence.
AFCE proportion among strokes fell after DOACs; hypothesis-generating for real-world prevention gains amid adherence gaps.
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Okabe et al. (2019) studied this question.
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