January 1, 2000Genetic Epidemiology
Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study
Population
455 randomly ascertained families from the NHLBI Family Heart Study (FHS)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Does not yet alter clinical spirometry interpretation; leaves open major gene mapping for FEV1 in diverse cohorts.
Structured PICO
P
Population
455 randomly ascertained families from the NHLBI Family Heart Study (FHS)
O
Outcome
Heritability and genetic models for forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the ratio of FEV1/FVC
Segregation analysis suggests a dominant major gene influences FEV1, while complex relationships involving multiple genes and environmental factors influence overall lung function traits.
Cite This Study
Wilk et al. (2000) studied this question.