Population
Xenopus oocytes expressing a slowly activating, voltage-dependent potassium channel protein cloned from rat…
Comparison
Protein kinase C activators vs Wild-type vs Ser103Ala mutant channels; presence…
Design
Preclinical
Authors
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Provides mechanistic insight into PKC regulation of K+ channels; leaves open relevance to human electrophysiology or therapy.
Inhibition of the cloned rat kidney potassium current by protein kinase C is mediated by direct phosphorylation at the Ser103 residue.
Büsch et al. (1992) studied this question.
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