Mendelian randomization reveals no robust causal links between migraine subtypes and six neuropsychiatric disorders, indicating shared associations may lack direct causation.
Our study aims to explore the causal relationship between migraine (with and without aura) and 6 disorders: anxiety, bipolar disorder, epilepsy, major depressive disorder, insomnia, and stroke, using a 2-sample Mendelian randomization. Migraine without aura had a significant causal association with bipolar disorder (odds ratios = 1.075, 95% confidence intervals = [1.005-1.151], P = .037). A complex relationship was found with major depressive disorder (odds ratios = 1.036, 95% confidence intervals = [1.009-1.064], P = .010 for overall migraine). But after correction for Benjamini-Hochberg multiple tests, no causal links were identified between migraine (with and without aura) and these 6 disorders (all PFDR > .05). Further biological and clinical studies are needed to validate these findings.
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Xu et al. (2025) studied this question.
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