What question did this study set out to answer?

To prospectively characterize recurrent chromosomal abnormalities and evaluate their prognostic relevance in untreated Waldenström's macroglobulinemia.

October 12, 2012HaematologicaOpen Access

Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia

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Authors

FNFlorence Nguyen‐KhacDélégation Paris 5 JLJérôme LambertInserm ÉCÉlise ChapiroInserm

Discussion

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Implication

Randomized trial reveals recurrent chromosomal abnormalities linked to shorter survival in Waldenström macroglobulinemia, indicating that cytogenetic profiling improves risk prognostication.

Key Points

To prospectively characterize recurrent chromosomal abnormalities and evaluate their prognostic relevance in untreated Waldenström's macroglobulinemia.
Prospective cytogenetic study nested within an international randomized trial evaluating N=174 previously untreated patients.
Assessed recurrent genetic abnormalities and correlated cytogenetic profiles with progression-free survival, disease-free survival, and clinical parameters.
Common aberrations included 6q deletions (30%), trisomy 18 (15%), 13q deletions (13%), 17p (TP53) deletions (8%), trisomy 4 (8%), and 11q (ATM) deletions (7%), whereas IGH translocations occurred in <5%.
Deletions of 6q and 11q along with trisomy 4 significantly associated with adverse clinical and biological parameters.
Patients with TP53 deletions experienced significantly shorter progression-free survival and disease-free survival, while rare trisomy 12 (<5%) also conferred shorter progression-free survival.

Cite This Study

Nguyen‐Khac et al. (2012) studied this question.

synapsesocial.com/papers/6a7d136945db7d096f6e4614 https://doi.org/10.3324/haematol.2012.070458

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Implication

Randomized trial reveals recurrent chromosomal abnormalities linked to shorter survival in Waldenström macroglobulinemia, indicating that cytogenetic profiling improves risk prognostication.

Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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