Why the study?
Angiogenesis is essential for repairing tissues subjected to ischemic injury, but whether the pro-angiogenic effect of Qiliqiangxin prescription is mediated through miR-21 signaling remained unknown.
Population
Primary CMECs from 2-3 weeks old SD rats
Comparison
1% O2 hypoxia vs normoxia with or without QL pretreatment and miR-21 modulation
Design
In vitro controlled laboratory study
Follow-up
24h
Authors
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Supports miR-21 mediation of QL angiogenesis in rat CMECs; hypothesis-generating for ischemic therapies.
Qiliqiangxin prescription promotes angiogenesis in hypoxic cardiac microvascular endothelial cells by activating the miR-21 and HIF-1α/VEGF pathway.
Wang et al. (2020) studied this question.
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