Why the study?
Does ApoAV deficiency alter triglyceride-rich lipoprotein metabolism in mice?
Population
apoa5(-/-) mice and controls
Comparison
ApoAV deficiency (apoa5(-/-) knockout model) vs Control mice
Design
Preclinical
Authors
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ApoAV deficiency impairs TRL clearance in mice; leaves open therapeutic targeting in human hypertriglyceridemia.
Does ApoAV deficiency alter triglyceride-rich lipoprotein metabolism in mice?
ApoAV deficiency leads to marked hypertriglyceridemia by impairing the lipolysis of triglyceride-rich lipoproteins and the clearance of their remnants.
Grosskopf et al. (2005) studied this question.