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October 1, 1998European Journal of Clinical Investigation

Increased risk for endogenous hypertriglyceridaemia is associated with an apolipoprotein C3 haplotype specified by the SstI polymorphism

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Why the study?

Is the SstI polymorphism in the APOC3 gene associated with an increased risk for endogenous hypertriglyceridaemia?

Population

Patients with distinct types of hypertriglyceridaemia: combined hyperlipidaemia, familial…

Comparison

APOC3 gene polymorphisms and haplotype analysis vs Control group and CHL patients

Design

Case-control

Authors

HHofferESEric J.G. SijbrandsDMde Man

Discussion

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Overview

APOC3 SstI haplotype associated with HTG risk; leaves open causal role and clinical utility pending replication.

Structured PICO

Is the SstI polymorphism in the APOC3 gene associated with an increased risk for endogenous hypertriglyceridaemia?

P
Population
Patients with distinct types of hypertriglyceridaemia: combined hyperlipidaemia (CHL), familial dysbetalipoproteinaemia (FD) and endogenous hypertriglyceridaemia (HTG), and a control group
I
Intervention
APOC3 gene polymorphisms (-482, -455, SstI) and haplotype analysis
C
Comparator
Control group and CHL patients
O
Outcome
Frequency of APOC3 promoter polymorphisms and SstI polymorphismsurrogate

The APOC3 haplotype containing the SstI polymorphism is strongly associated with an increased risk for severe endogenous hypertriglyceridaemia.

Cite This Study

Hoffer et al. (1998) studied this question.

synapsesocial.com/papers/6a7d1771c7e6f6a50737cd88https://doi.org/10.1046/j.1365-2362.1998.00361.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.1993 · 227 citations
  2. 2Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.1995 · 282 citations
  3. 3Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects1996 · 40 citations
  4. 4Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.1985 · 415 citations
  5. 5Inhibition of lipoprotein lipase activity by synthetic peptides of apolipoprotein C-III.1992 · 177 citations