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May 15, 1993Proceedings of the National Academy of SciencesOpen Access

An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.

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Why the study?

Are specific apolipoprotein CIII promoter and 3' untranslated region haplotypes associated with the risk of severe hypertriglyceridemia in adults?

Population

157 adults, comprising 78 normolipidemic adults and 79 adults with severe hypertriglyceridemia (HTG)

Comparison

Apolipoprotein CIII promoter/Sst I haplotypes vs Other haplotypes lacking the specific alleles

Design

Case-control

Authors

MDMarilyn DammermanLSLodewijk A. SandkuijlJHJeffrey L. Halaas

Discussion

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Overview

Apolipoprotein CIII haplotypes may modulate severe HTG susceptibility; hypothesis-generating and requires prospective validation before clinical consideration.

Key Points

  • This research aims to identify specific haplotypes in the apolipoprotein CIII gene that influence the risk of hypertriglyceridemia.
  • Analyzed five DNA polymorphisms in the apolipoprotein CIII gene promoter and 3' untranslated region.
  • Eighty-nine adults (79 with severe hypertriglyceridemia and 78 normolipidemic) were studied.
  • Used maximum likelihood analysis to estimate haplotype distribution.
  • 211 haplotype was 3.8-fold more common in normolipidemic subjects (0.186) compared to HTG subjects (0.049).
  • 211 haplotype associated with reduced HTG risk (relative risk 0.28; P = 0.005).
  • 222 haplotype linked to increased HTG risk (relative risk 3.14; P < 0.0025).

Structured PICO

Are specific apolipoprotein CIII promoter and 3' untranslated region haplotypes associated with the risk of severe hypertriglyceridemia in adults?

P
Population
157 adults, comprising 78 normolipidemic adults and 79 adults with severe hypertriglyceridemia (HTG)
I
Intervention
Apolipoprotein CIII promoter/Sst I haplotypes (specifically 211 and 222 haplotypes)
C
Comparator
Other haplotypes lacking the specific alleles
O
Outcome
Risk of severe hypertriglyceridemia (HTG)surrogate

Specific apolipoprotein CIII promoter and 3' untranslated region haplotypes confer either protection against or susceptibility to severe hypertriglyceridemia.

Cite This Study

Dammerman et al. (1993) studied this question.

synapsesocial.com/papers/6a20b06fac4c2e2edfeb88e6https://doi.org/10.1073/pnas.90.10.4562
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Strong association of a single nucleotide substitution in the 3'-untranslated region of the apolipoprotein-CIII gene with common hypertriglyceridemia in Arabs.1989 · 64 citations
  2. 2Plasma triglyceride and coronary heart disease.1991 · 703 citations
  3. 3Role of Insulin Resistance in Human Disease1988 · 12,160 citations
  4. 4Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.1985 · 315 citations
  5. 5Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.1990 · 109 citations