Key result
Rare apo-CIII SstI G allele is linked to ~2-fold higher prevalence of high triglycerides.
Why the study?
Is the apolipoprotein CIII SstI polymorphism associated with high plasma triglyceride levels in a Japanese population living in Southern Brazil?
Observational (n=159)
Is the apolipoprotein CIII SstI polymorphism associated with high plasma triglyceride levels in a Japanese population living in Southern Brazil?
The rare G allele of the apo-CIII SstI polymorphism is highly prevalent and significantly associated with high triglyceride levels in Japanese individuals living in Southern Brazil.
Supports apo-CIII SstI G allele link to hypertriglyceridemia in Japanese-Brazilians; hypothesis-generating, needs prospective validation before any clinical use.
Apolipoprotein CIII (apo-CIII) participates in the regulation of triglyceride-rich lipoprotein metabolism. Several polymorphic sites have been detected within and around the apo-CIII gene. Here, we examined the relationship between apo-CIII SstI polymorphism (CC, CG, GG genotypes) and plasma triglyceride (TG) levels in a group of 159 Japanese individuals living in Southern Brazil. The sample was divided into a group of Japanese descendants (N = 51) with high TG (HTG; >200 mg/dL) and a group of Japanese descendants (N = 108) with normal TG (NTG; <200 mg/dL). TG and total cholesterol levels were analyzed by an enzymatic method using the Labtest-Diagnostic kit and high- and low-density lipoproteins by a direct method using the Labtest-Diagnostic kit and DiaSys Diagnostic System International kit, respectively. A 428-bp sequence of apo-CIII gene was amplified using oligonucleotide primers 5' GGT GAC CGA TGG CTT CAG TTC CCT GA 3' and 5' CAG AAG GTG GAT AGA GCG CTG GCC T 3'. The PCR products were digested with a restriction endonuclease SstI. Rare G allele was highly prevalent in our study population (0.416) compared to Caucasians (0.00-0.11). G allele was almost two times more prevalent in the HTG group compared to the NTG group (P < 0.001). The genotype distribution was consistent with the Hardy-Weinberg equilibrium. There was a significant association between rare G allele and HTG in Japanese individuals living in Southern Brazil as indicated by one-way ANOVA, P < 0.05.
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Parzianello et al. (2008) conducted an observational in Hypertriglyceridemia (n=159). Apolipoprotein CIII SstI polymorphism (rare G allele) vs. Normal triglyceride levels (<200 mg/dL) was evaluated on High triglyceride levels (>200 mg/dL) (p=<0.001). The rare G allele of the apolipoprotein CIII SstI polymorphism was almost twice as prevalent in the high triglyceride group compared to the normal triglyceride group (P<0.001).
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