Key result
The rare S2S2 genotype of the APOC3 SstI polymorphism was significantly associated with a nearly 10-fold increased odds of hypertriglyceridemia compared to the S1S1 genotype in Asian Indian men (OR 9.9).
Why the study?
Does the APOC3 SstI polymorphism associate with hypertriglyceridemia in healthy male Asian Indians?
Population
139 male healthy volunteers from Northern India
Comparison
APOC3 SstI polymorphism (S1S2 and S2S2 genotypes) vs S1S1 genotype
Design
Cross-sectional
Authors
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Association warrants further study in Asian Indian men; hypothesis-generating and should not change practice.
Cross-Sectional (n=139)
No
Does the APOC3 SstI polymorphism associate with hypertriglyceridemia in healthy male Asian Indians?
Odds Ratio: 9.9 (95% CI 2.66–37.29)
Absolute Event Rate: 61.5% vs 13.8%
p-value: p=0.0006
The rare S2 allele of the APOC3 gene is highly prevalent and significantly associated with hypertriglyceridemia in Asian Indian males.
Chhabra et al. (2002) conducted a cross-sectional in Hypertriglyceridemia (n=139). APOC3 SstI polymorphism (S2S2 genotype) vs. S1S1 genotype was evaluated on Hypertriglyceridemia (TG > 1.921 mmol/L) (OR 9.9, 95% CI 2.66-37.29, p=0.0006). The rare S2S2 genotype of the APOC3 SstI polymorphism was significantly associated with a nearly 10-fold increased odds of hypertriglyceridemia compared to the S1S1 genotype in Asian Indian men (OR 9.9).
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