March 1, 1995Clinical Cardiology
Malignant coronary artery disease in young asian indians: Thoughts on pathogenesis, prevention, and therapy
Population
Young Asian Indians at risk for or with coronary artery disease
Design
Review
Authors
Discussion
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Implication
May inform ethnicity-specific CAD risk assessment; leaves open prospective trials to validate aggressive prevention.
Key Points
- To examine the risk profiles, clinical patterns, and therapeutic strategies associated with early-onset, severe coronary artery disease in Asian Indians.
- Synthesized clinical and epidemiological evidence regarding coronary artery disease incidence and cardiovascular risk factors among Asian Indian populations.
- Evaluated metabolic profiles including lipid parameters, insulin levels, and body fat distribution alongside preventative lifestyle and medical interventions.
- Asian Indians exhibit the highest rates of early-onset, rapidly progressive coronary artery disease of any studied ethnic group despite low traditional risk factors and high rates of lifelong vegetarianism.
- High prevalence rates of elevated triglycerides, low high-density lipoprotein cholesterol, high lipoprotein(a), hyperinsulinemia, and abdominal obesity characterize this population.
- Aggressive lifestyle modifications initiated prior to adolescence and early primary pharmacotherapy analogous to secondary prevention are recommended for high-risk individuals.
Structured PICO
P
Population
Young Asian Indians at risk for or with coronary artery disease
I
Intervention
Aggressive lifestyle modification and pharmacologic intervention
O
Outcome
Prevention of coronary artery disease
Highlights the unique, high-risk metabolic profile of young Asian Indians and advocates for aggressive early lifestyle and pharmacologic interventions for primary prevention of CAD.
Cite This Study
Enas et al. (1995) studied this question.