Key result
The 3.2-kb allele in the apolipoprotein C-III gene was found in a significantly increased prevalence among Caucasian hypertriglyceridemic subjects (allele frequency 0.19) compared to race-matched controls (0) (P < 0.001).
Why the study?
Is a DNA sequence polymorphism in the apolipoprotein C-III gene associated with hypertriglyceridemia in Caucasian subjects?
Population
Caucasian hypertriglyceridemic subjects, race-matched controls, and normal individuals of differing racial…
Comparison
Presence of a DNA sequence polymorphism in or… vs Race-matched controls without hypertriglyceridemia
Design
Case-control
Authors
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No immediate change to hypertriglyceridemia management; leaves open causal role of the 3.2-kb allele.
Case-Control (n=215)
Is a DNA sequence polymorphism in the apolipoprotein C-III gene associated with hypertriglyceridemia in Caucasian subjects?
Absolute Event Rate: 19% vs 0%
p-value: p=<0.001
A specific DNA polymorphism in the apolipoprotein C-III gene is significantly associated with hypertriglyceridemia in Caucasian populations.
Rees et al. (1985) conducted a case-control in Hypertriglyceridemia (n=215). Sst-1 polymorphism (3.2-kb allele) in the apolipoprotein A-1-C-III gene cluster vs. Absence of the 3.2-kb allele (common 4.2-kb allele) was evaluated on Frequency of the 3.2-kb allele (p=<0.001). The 3.2-kb allele in the apolipoprotein C-III gene was found in a significantly increased prevalence among Caucasian hypertriglyceridemic subjects (allele frequency 0.19) compared to race-matched controls (0) (P < 0.001).
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