What does this research mean for the field?

Hyperlipoproteinaemia types IV and V within familial clusters do not strictly conform to standard autosomal dominant, autosomal recessive, or multiple-type inheritance models. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1977Clinical Genetics

Genetic study of hyperlipoproteinaemia types IV and V

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Key result

Hyperlipoproteinemia types IV and V affect three generations without fitting standard inheritance models.

Population

32 members of a single family across three generations

Design

Case_series

Authors

JFJ. FrançoisCentre Hospitalier Régional de Metz-Thionville FLF. LentiniMRC Laboratory of Molecular Biology PHP. Hose

Discussion

Member takes

Implication

Does not fit Mendelian models for counseling; leaves open complex inheritance requiring larger genomic studies.

Structured PICO

Population

32 members of a single family across three generations (21 normal, 11 affected by hyperlipoproteinaemia types IV and V or related biological disorders)

Outcome

Inheritance pattern of hyperlipoproteinaemia types IV and V

The inheritance pattern of hyperlipoproteinaemia types IV and V remains complex, as standard Mendelian patterns could not fully explain the transmission in this family.

Cite This Study

François et al. (1977) studied this question. Hyperlipoproteinaemia types IV and V affected 11 of 32 family members across three generations without clearly fitting autosomal dominant, recessive, or multiple-type inheritance models.

synapsesocial.com/papers/6aa776b367c2e25ec0038cee https://doi.org/10.1111/j.1399-0004.1977.tb00927.x

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Genetic study of hyperlipoproteinaemia types IV and V

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic study of hyperlipoproteinaemia types IV and V

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider