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August 1, 1996Arteriosclerosis Thrombosis and Vascular Biology

Polymorphic Markers in Apolipoprotein C-III Gene Flanking Regions and Hypertriglyceridemia

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Why the study?

Is the Sst I polymorphism in the apo C-III gene associated with hypertriglyceridemia?

Population

Individuals from the ARIC study

Comparison

Sst I polymorphism in the 3'-untranslated region… vs Individuals without the specific polymorphisms…

Design

Cohort

Authors

ASAndrei SurguchovUniversity Medical CenterGPGrier P. PageRTI InternationalLSLouis C. SmithUniversity of California, San Francisco

Discussion

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Implication

Does not support routine Sst I testing in hypertriglyceridemia; leaves open causal role and need for prospective validation.

Structured PICO

Is the Sst I polymorphism in the apo C-III gene associated with hypertriglyceridemia?

P
Population
Individuals from the ARIC study
I
Intervention
Sst I polymorphism in the 3'-untranslated region and 5' regulatory region polymorphisms of the apo C-III gene
C
Comparator
Individuals without the specific polymorphisms or with low triglyceride levels
O
Outcome
Hypertriglyceridemiasurrogate

The Sst I polymorphism in the apo C-III gene is strongly associated with hypertriglyceridemia, independent of 5' regulatory region variations.

Cite This Study

Surguchov et al. (1996) studied this question.

synapsesocial.com/papers/6a72890de5469ee92be27397https://doi.org/10.1161/01.atv.16.8.941
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,641 citations
  2. 2Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.1988 · 110 citations
  3. 3Plasma Triglyceride Level and Mortality from Coronary Heart Disease1993 · 427 citations
  4. 4Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans.1994 · 28 citations