What question did this study set out to answer?

To assess the long-term incidence and relative risk of second intracranial tumors in patients receiving conservative surgery and external beam radiotherapy for pituitary adenoma.

February 1, 2005The Journal of Clinical Endocrinology & MetabolismOpen Access

Risk of Second Brain Tumor after Conservative Surgery and Radiotherapy for Pituitary Adenoma: Update after an Additional 10 Years

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To assess the long-term incidence and relative risk of second intracranial tumors in patients receiving conservative surgery and external beam radiotherapy for pituitary adenoma.
Retrospective cohort analysis of 426 United Kingdom patients with pituitary adenomas treated with radiotherapy at the Royal Marsden Hospital between 1962 and 1994, with 5,749 person-years of follow-up.
Cumulative incidence of second brain tumors and systemic malignancies was compared to regional and national registries (Thames Cancer Registry and NHS Central Register).
Eleven patients developed second brain tumors (five meningiomas, four astrocytomas, one meningeal sarcoma, and one primitive neuroectodermal tumor), corresponding to a cumulative risk of 2.0% (95% CI, 0.9–4.4%) at 10 years and 2.4% (95% CI, 1.2–5.0%) at 20 years.
The overall relative risk of a second brain tumor was 10.5 (95% CI, 4.3–16.7), with an RR of 7.0 for neuroepithelial tumors and 24.3 for meningeal tumors.
Interval relative risks were 24.2 (95% CI, 4.8–43.5) at 5–9 years, 2.9 (95% CI, 0–8.5) at 10–19 years, and 28.6 (95% CI, 0.6–56.6) beyond 20 years, without evidence of increased systemic cancer risk.

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Implication

Cohort study reveals an elevated long-term risk of second brain tumors after pituitary adenoma radiotherapy, highlighting the need for lifelong surveillance despite low absolute incidence.

Cite This Study

Minniti et al. (2005) studied this question.

synapsesocial.com/papers/6a7d178db0b0e582d537cf77 https://doi.org/10.1210/jc.2004-1152

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Implication

Cohort study reveals an elevated long-term risk of second brain tumors after pituitary adenoma radiotherapy, highlighting the need for lifelong surveillance despite low absolute incidence.

Risk of Second Brain Tumor after Conservative Surgery and Radiotherapy for Pituitary Adenoma: Update after an Additional 10 Years

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Discussion

Implication

Cite This Study

Risk of Second Brain Tumor after Conservative Surgery and Radiotherapy for Pituitary Adenoma: Update after an Additional 10 Years

Key Points

Discussion

Implication

Cite This Study

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