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Recent efforts in these laboratories have resulted in the development of a synthetic approach to C(7) alkyl analogs in the K252a class of indolocarbazole natural products. Synthesis of 7(R)-methyl K252a (3a) and 7-(S)-methyl K252a (3b) will be described along with their activity against protein tyrosine kinases.
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John L. Wood (1999) studied this question.
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