Risk factors for in-hospital mortality among acute ischemic stroke patients in China: a nationwide prospective study

Objective: We aimed to investigate factors related to in-hospital mortality (IHM) in acute ischemic stroke (AIS) patients.Methods: We prospectively investigated 827,314 patients who were admitted within 7 days of AIS between August 2015 and July 2019. Demographic characteristics, risk factors, and clinical and laboratory characteristics of patients were assessed. Univariate and multivariate logistic regression analyses were performed to identify predictors associated with IHM.Results: The IHM rate in this study was 0.5% in women and 0.3% in men. Factors associated with IHM in AIS included diabetes (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.03–1.43), female (OR 0.84, 95%CI 0.74–0.96), hypertension (OR 1.16, 95%CI 1.01–1.34), atrial fib/flutter (OR 1.51, 95%CI 1.29–1.77), other heart disease (OR1.43, 95%CI 1.23–1.67), prior myocardial infarction (OR 2.00, 95%CI 1.54–2.60), antiplatelet therapies (OR 0.71, 95%CI 0.60–0.84), gastrointestinal bleeding (OR 3.54, 95%CI 2.83–4.44), pulmonary embolism (OR 2.53, 95%CI1.41–4.53), dysphagia(OR7.32, 95%CI6.23–8.61), glycosylated hemoglobin (OR1.05, 95%CI 1.02–1.09), serum creatinine (OR 1.001, 95%CI 1.001–1.002), urea nitrogen (OR 1.10, 95%CI 1.08–1.12), National Institutes of Health Stroke Scale (NIHSS) score (4–5 vs. 0–4: OR 3.58; ≥15 vs. 0–4: OR 8.78), stroke rehabilitation (OR 0.27, 95%CI 0.23–0.30), age (third IQR vs. first IQR: OR 1.57; fourth IQR vs. first IQR: OR 2.23), and in-hospital stroke/TIArecurrence (OR 2.38, 95%CI 2.03–2.78).Conclusions: The findings from this study may help clinicians control the risk of IHM better for patients with AIS.