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May 22, 2019Journal of Clinical OncologyOpen Access

Treatment and Long-Term Clinical Outcomes of Incidental Pulmonary Embolism in Patients With Cancer: An International Prospective Cohort Study

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Why the study?

The clinical relevance and optimal therapy for incidental pulmonary embolism in patients with cancer, particularly distal clots, remained unclear.

Population

695 unselected adults with active cancer and a recent diagnosis of incidental pulmonary embolism

Comparison

Subsegmental pulmonary embolism vs more proximal pulmonary embolism

Design

International prospective observational cohort study

Follow-up

12 months

Authors

NKNoémie KraaijpoelVascular MedicineSBSuzanne M. BlekerAmsterdam University Medical CentersGMGuy MeyerVascular Medicine

Discussion

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Implication

Recurrent VTE risk remains clinically relevant in treated cancer patients with incidental PE; leaves open optimal duration and subsegmental strategies.

Structured PICO

P
Population
695 unselected adults with active cancer and a recent diagnosis of incidental pulmonary embolism, mean age 66 years, 58% male, international.
I
Intervention
Anticoagulant therapy (initiated in 97% of patients, of whom 89% received low-molecular-weight heparin)
O
Outcome
Recurrent venous thromboembolism, major bleeding, and all-cause mortality during 12 months of follow-up, centrally adjudicatedhard clinical

In patients with cancer and incidental pulmonary embolism, the risk of recurrent venous thromboembolism remains significant despite anticoagulant treatment, and is comparable between subsegmental and more proximal clots.

Cite This Study

Kraaijpoel et al. (2019) studied this question.

synapsesocial.com/papers/6a7d1aefade38b7dc346cebdhttps://doi.org/10.1200/jco.18.01977

Topics

Pulmonary embolism
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Also Consider

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