Why the study?
Does ORG6001 reduce the incidence of ventricular ectopic beats in anaesthetized greyhounds following acute coronary artery ligation?
Population
Anaesthetized greyhounds with experimental acute myocardial infarction induced by ligation of the left…
Comparison
ORG6001 administered intravenously or orally vs Control animals
Design
Preclinical
Follow-up
30 min
Authors
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No clinical implications yet; leaves open translation of amino-steroid antiarrhythmics to human ischaemic arrhythmias.
Does ORG6001 reduce the incidence of ventricular ectopic beats in anaesthetized greyhounds following acute coronary artery ligation?
In a canine model of acute myocardial infarction, the novel amino steroid ORG6001 significantly reduced early ventricular arrhythmias and metabolic signs of ischaemia with minimal haemodynamic effects.
Marshall et al. (1975) studied this question.
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