Why the study?
Does hormone replacement therapy affect serum lipid profiles differently based on hepatic lipase polymorphism in postmenopausal Japanese women?
Population
209 postmenopausal Japanese women
Comparison
Hormone replacement therapy (HRT) for 3 months vs Baseline (before HRT)
Design
Cohort
Follow-up
3 months
Authors
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HRT lipid effects appear genotype-independent in this cohort; leaves open confirmation in randomized trials before guiding practice.
Does hormone replacement therapy affect serum lipid profiles differently based on hepatic lipase polymorphism in postmenopausal Japanese women?
Hormone replacement therapy improves lipid profiles in postmenopausal Japanese women regardless of hepatic lipase polymorphism, although baseline lipid levels vary by genotype.
Somekawa et al. (2002) studied this question.
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