Why the study?
Does acute adrenoceptor blockade with prazosin, atenolol, or propranolol alter hemodynamic and metabolic responses to exercise after glycogen depletion in humans?
Population
Humans undergoing acute exercise 2 h after prolonged prior exercise to induce skeletal muscle glycogen…
Comparison
Acute alpha 1-adrenoceptor blockade with… vs Placebo
Authors
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May warrant caution with nonselective beta-blockade in glycogen-depleted exercise; leaves open beta-2 receptor contributions to hepatic glucose production.
Does acute adrenoceptor blockade with prazosin, atenolol, or propranolol alter hemodynamic and metabolic responses to exercise after glycogen depletion in humans?
Nonselective beta-blockade with propranolol impairs hepatic glucose production during exercise after glycogen depletion, highlighting the role of beta-2 receptors in maintaining plasma glucose.
McLeod et al. (1984) studied this question.
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