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August 19, 2009Journal of Hypertension

Reactive oxygen species-mediated effects on vascular remodeling induced by human atrial natriuretic peptide T2238C molecular variant in endothelial cells in vitro

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Population

Human umbilical vein endothelial cells in vitro

Comparison

Exposure to mutant (CC2238) alpha-ANP vs Exposure to wild-type (TT2238) alpha-ANP

Design

Preclinical

Authors

SSStefania ScarpinoCTO Andrea AlesiniSMSimona MarchittiRutgers, The State University of New JerseyRSRosita StanzioneIstituto Neurologico Mediterraneo

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Implication

Hypothesis-generating for CC2238 alpha-ANP in endothelial dysfunction; leaves open clinical translation and requires human validation.

Structured PICO

P
Population
Human umbilical vein endothelial cells in vitro
I
Intervention
Exposure to mutant (CC2238) alpha-ANP
C
Comparator
Exposure to wild-type (TT2238) alpha-ANP
O
Outcome
Oxidative stress production, cell proliferation and migration, angiogenesis and vascular remodelingsurrogate

The CC2238 alpha-ANP variant induces ROS accumulation and impairs endothelial cell function in vitro, providing a potential mechanism for its association with increased cardiovascular risk.

Cite This Study

Scarpino et al. (2009) studied this question.

synapsesocial.com/papers/6a7d23752ad457ac68775288https://doi.org/10.1097/hjh.0b013e32832d229f
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Also Consider

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  1. 1Autocrine and paracrine effects of atrial natriuretic peptide gene transfer on vascular smooth muscle and endothelial cellular growth.1994 · 78 citations
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  4. 4Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 32007 · 108 citations
  5. 5Natriuretic Peptides and Mortality After Stroke2005 · 164 citations