October 1, 1993BloodOpen Access

Defective adhesion of blood platelets to vascular microfibrils in the Bernard-Soulier syndrome

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Population

Platelets from 2 patients with Bernard-Soulier syndrome (BSS) with low platelet count

Design

Preclinical

Authors

FFF. Fauvel-LafèveCentre National de la Recherche Scientifique VTV TabakaInserm JCJP CaenCentre National de la Recherche Scientifique

Discussion

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Implication

Suggests GPIb-IX dependence in MF adhesion; leaves open whether this axis influences clinical bleeding or thrombosis risk.

Structured PICO

Population

Platelets from 2 patients with Bernard-Soulier syndrome (BSS) with low platelet count

Intervention

In vitro adhesion assay to subendothelial microfibrils (MFs) and type I collagen, including testing with monoclonal antibody AN51

Outcome

Platelet adhesion to subendothelial microfibrils and type I collagensurrogate

The study demonstrates that platelet adhesion to subendothelial microfibrils requires the GPIb-IX complex, establishing the importance of the MFs-vWF-GPIb-IX axis in platelet reactivity.

Cite This Study

Fauvel-Lafève et al. (1993) studied this question.

synapsesocial.com/papers/6a7d24adff1a536db837d11c https://doi.org/10.1182/blood.v82.7.1985.1985

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Defective adhesion of blood platelets to vascular microfibrils in the Bernard-Soulier syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Defective adhesion of blood platelets to vascular microfibrils in the Bernard-Soulier syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider