Why the study?
Does whole exome sequencing improve the rate of genetic diagnosis compared to commercially available genetic panels in adults with inherited cardiovascular diseases?
Population
200 adult patients with inherited cardiovascular disease evaluated at the Yale Program for Cardiovascular…
Comparison
Whole exome sequencing vs Commercially available genetic panels
Design
Cohort
Authors
Loading...
Whole exome sequencing was associated with higher diagnostic yield; leaves open its role versus panels before changing practice in inherited cardiovascular disease.
Does whole exome sequencing improve the rate of genetic diagnosis compared to commercially available genetic panels in adults with inherited cardiovascular diseases?
Whole exome sequencing significantly increases the diagnostic yield for inherited cardiovascular diseases compared to standard commercial genetic panels, particularly in cases of aborted sudden cardiac death.
Seidelmann et al. (2017) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: