August 1, 2006British Journal of PharmacologyOpen Access

Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations

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Population

Isolated smooth muscle and platelet preparations

Design

Preclinical

Authors

RJRebecca L. JonesAzienda Ospedaliera Citta' della Salute e della Scienza di Torino HWHelen WiseHeriot-Watt University RCR.G. ClarkUniversity of Strathclyde

Discussion

Member takes

Implication

RO1138452 offers a selective IP probe for isolated-vessel studies; leaves open in vivo and clinical translation.

Structured PICO

Population

Isolated smooth muscle (human pulmonary artery, guinea-pig aorta, rabbit mesenteric artery, guinea-pig trachea) and platelet preparations (human and rat platelet-rich plasmas)

Intervention

RO1138452 (prostacyclin IP receptor antagonist)

Outcome

pA2 values for antagonism of relaxation and platelet aggregationsurrogate

RO1138452 is demonstrated to be a potent and selective prostacyclin (IP) receptor antagonist in isolated blood vessel and platelet preparations.

Cite This Study

Jones et al. (2006) studied this question.

synapsesocial.com/papers/6a7d24ede6f633beba6e4bb8 https://doi.org/10.1038/sj.bjp.0706841

Topics

Thymosin beta-4

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Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider