Changes in Inflammatory Markers in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty

Figures

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  Figure 1. Serum concentrations of biomarkers before and 24 h after a single BPA session. There were increases in concentrations of IL-6 (∆ = 3.67 (1.41; 7.16); p < 0.001), of IL10 (∆ = 0.25 (0; 0.47); p = 0.003), of MCP-1 (∆ = 111 (60.1; 202.8); p = 0.002), and of hsCRP (∆ = 4.81 (3.46; 8.47); p < 0.001), and no change in IL-8 (∆ = 0.12 (−5.44; 5.23); p = 0.92), or ET-1 (∆ = −0.2 (−0.5; 0.23); p = 0.20). The orange color indicates an increase, and the blue color indicates a decrease. The difference between the two time points was determined using the Wilcoxon matched-pairs signed-rank test.

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  Figure 2. Serum concentrations of biomarkers before and after completion of BPA treatment. There was a decrease in concentrations of IL-6 (∆ = −1.61 (−3.11; −0.20); p = 0.03), of IL8 (∆ = −3.24 (−7.72; 0.82); p = 0.01), and of ET-1 (∆ = −0.47 (−0.96; 0.05); p = 0.005). The orange color indicates an increase, and the blue color indicates a decrease. The difference between the two time points was determined using the Wilcoxon matched-pairs signed-rank test.

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  Figure 3. Serum concentrations of endothelin 1, interleukin 6, and interleukin 8 at different time points (baseline, after single BPA session, after completion of BPA treatment) during BPA treatment as compared to control group. IL-6 and IL-8 levels normalized after completion of BPA treatment. The difference between the two time points in the CTEPH group was determined using the Wilcoxon matched-pairs signed-rank test. The difference between the CTEPH group and the controls was determined using the Mann–Whitney U test.