Why the study?
Does aminoguanidine reduce myocardial damage in rats with experimental autoimmune myocarditis?
Population
20 Lewis rats with experimental autoimmune myocarditis induced by injection of porcine cardiac myosin
Comparison
Aminoguanidine, an inhibitor of inducible NO… vs No aminoguanidine treatment
Design
Preclinical
Authors
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AG reduces inflammation in rat EAM; leaves open whether iNOS inhibition benefits human myocarditis.
Does aminoguanidine reduce myocardial damage in rats with experimental autoimmune myocarditis?
Inhibition of iNOS with aminoguanidine significantly reduces myocardial damage and inflammatory cell infiltration in a rat model of experimental autoimmune myocarditis.
Ishiyama et al. (1997) studied this question.
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