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We present here the first catalytic desymmetrization of the 2,2′,6,6′‐tetrabromobiphenyl 1 and analogues, by a bromine‐lithium exchange catalyzed by either diamines or diether derivatives (0.5 equiv.), yielding axially chiral compounds in high yield (up to 89%) and high enantioselectivity (up to 82%).
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Perron et al. (2010) studied this question.
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