What question did this study set out to answer?

To compare clinical outcomes and antibiotic utilization between bronchoalveolar lavage with quantitative culture and endotracheal aspiration with nonquantitative culture in patients with suspected ventilator-associated pneumonia.

December 20, 2006New England Journal of MedicineOpen Access

A Randomized Trial of Diagnostic Techniques for Ventilator-Associated Pneumonia

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Implication

Randomized trial reveals similar 28-day mortality between lavage and aspiration diagnostics in ventilated patients, suggesting noninvasive endotracheal sampling is adequate for guided care.

Key Points

To compare clinical outcomes and antibiotic utilization between bronchoalveolar lavage with quantitative culture and endotracheal aspiration with nonquantitative culture in patients with suspected ventilator-associated pneumonia.
Multicenter randomized trial enrolling 740 immunocompetent adults receiving mechanical ventilation with suspected ventilator-associated pneumonia across 28 ICUs in Canada and the United States (ISRCTN51767272).
Patients were randomly assigned to undergo either bronchoalveolar lavage with quantitative culture or endotracheal aspiration with nonquantitative culture, followed by empirical antibiotics and culture-directed targeted therapy.
The primary outcome of 28-day mortality did not differ significantly between the bronchoalveolar-lavage and endotracheal-aspiration groups (18.9% vs. 18.4%; P=0.94).
Rates of targeted antibiotic therapy (74.2% vs. 74.6%; P=0.90) and mean days alive without antibiotics (10.4±7.5 vs. 10.6±7.9 days; P=0.86) were similar between arms.
Maximum organ-dysfunction scores (mean 8.3±3.6 vs. 8.6±4.0; P=0.26) and lengths of stay in both the ICU and hospital showed no significant differences.

Cite This Study

A 2006 study studied this question.

synapsesocial.com/papers/6a7d2e46d85f1805a31cd002 https://doi.org/10.1056/nejmoa052904

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Implication

Randomized trial reveals similar 28-day mortality between lavage and aspiration diagnostics in ventilated patients, suggesting noninvasive endotracheal sampling is adequate for guided care.

A Randomized Trial of Diagnostic Techniques for Ventilator-Associated Pneumonia

Discussion

Member takes

Implication

Key Points

Cite This Study

A Randomized Trial of Diagnostic Techniques for Ventilator-Associated Pneumonia

Discussion

Member takes

Implication

Key Points

Cite This Study

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