May 24, 1994Proceedings of the National Academy of SciencesOpen Access

T-cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients.

View Full Paper

Ask AI

Bookmark

Population

29 sarcoidosis patients and 15 control subjects

Design

Cross-sectional

Authors

JGJohan GrünewaldUniversity Hospital Leipzig OOOlle OlerupKarolinska University Hospital UPU PerssonBrigham and Women's Hospital

Discussion

Member takes

Implication

Associates HLA-DR3,DQ2 haplotype with lung T-cell expansions in sarcoidosis; hypothesis-generating and should not yet change practice.

Structured PICO

Population

29 sarcoidosis patients and 15 control subjects

Comparator

15 control subjects

Outcome

T-cell receptor (TCR) variable region (V) gene usage by CD4+ and CD8+ lung and peripheral blood T cellssurrogate

In sarcoidosis patients, TCR V alpha 2.3+ CD4+ lung T-cell expansions are strongly correlated with the HLA-DR3(17),DQ2 haplotype and may be associated with clinical signs of disease activity.

Cite This Study

Grünewald et al. (1994) studied this question.

synapsesocial.com/papers/6a7d2ea986f53b502d964fdf https://doi.org/10.1073/pnas.91.11.4965

View Full Paper

Ask AI

Bookmark