What question did this study set out to answer?

To determine the genomic organization, sequence conservation, and developmental expression patterns of the rat neuropeptide Y gene.

April 1, 1987Proceedings of the National Academy of SciencesOpen Access

Structure and expression of the rat neuropeptide Y gene.

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To determine the genomic organization, sequence conservation, and developmental expression patterns of the rat neuropeptide Y gene.
Cloned and structurally analyzed the 7.2-kilobase pair genomic sequence encoding the rat neuropeptide Y precursor across its four exons.
Identified sequence polymorphisms across two alleles within a 2.5-kilobase pair region in the 5' flanking promoter sequence.
Profiled neuropeptide Y mRNA expression across embryonic and adult rat brain subregions as well as peripheral tissues.
The gene spans 7.2 kilobase pairs across four exons with an exon organization identical to pancreatic polypeptide, encoding a mature peptide identical to human neuropeptide Y.
Brain neuropeptide Y mRNA is detectable as early as embryonic day 16, rapidly climbs to adult levels, and appears throughout all tested brain regions.
High levels of neuropeptide Y mRNA were detected in peripheral organs, specifically the heart and spleen, suggesting expression in intrinsic ganglia and non-neuronal cells.

Authors

DLDan LarhammarUppsala University AEAnders EricssonLund University HPH PerssonKarolinska Institutet

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Implication

Gene characterization study reveals widespread neural and peripheral expression of neuropeptide Y in rats, highlighting conserved developmental regulation.

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Larhammar et al. (1987) studied this question.

synapsesocial.com/papers/6a7d2eedd85f1805a31cd03d https://doi.org/10.1073/pnas.84.7.2068

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Implication

Gene characterization study reveals widespread neural and peripheral expression of neuropeptide Y in rats, highlighting conserved developmental regulation.

Structure and expression of the rat neuropeptide Y gene.

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Discussion

Implication

Cite This Study

Structure and expression of the rat neuropeptide Y gene.

Key Points

Discussion

Implication

Cite This Study

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