Population
Hearts from hatched chicks at 2-3 days
Comparison
Intravenous administration of pertussis toxin vs Intravenous saline
Design
Preclinical
Follow-up
2-3 days
Authors
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Remains preclinical without direct clinical application; extends evidence for G-protein mediation of muscarinic atrial effects.
Pertussis toxin blocks carbachol-induced hyperpolarization in chick atrium, implicating a GTP-dependent protein in muscarinic regulation of atrial potassium channels.
Sorota et al. (1985) studied this question.
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