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January 1, 2014International Heart JournalOpen Access

Plaque Quantification by Coronary CT and Intravascular Ultrasound Identifies a Low CT Density Core as a Marker of Plaque Instability in Acute Coronary Syndromes

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Why the study?

Does a low-density core on CCTA correlate with IVUS-derived markers of plaque vulnerability in patients with acute coronary syndromes?

Population

43 patients with acute coronary syndromes (ACS) with 105 coronary plaques

Comparison

Coronary computed tomography angiography and… vs Culprit lesions versus non-culprit lesions

Design

Cross-sectional

Authors

TBTheodora BenedekJBJakó BeátaIBImre Benedek

Discussion

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Overview

LDC on CCTA may mark vulnerable plaque in ACS; leaves open prospective outcome validation before clinical adoption.

Structured PICO

Does a low-density core on CCTA correlate with IVUS-derived markers of plaque vulnerability in patients with acute coronary syndromes?

P
Population
43 patients with acute coronary syndromes (ACS) with 105 coronary plaques
I
Intervention
Coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS) for plaque quantification
C
Comparator
Culprit lesions versus non-culprit lesions
O
Outcome
Correlation between the presence and amount of a low-density core (LDC) < 30 Hounsfield units by CCTA and IVUS-derived markers of vulnerabilitysurrogate

A low-density core (<30 HU) on CCTA serves as a marker of plaque vulnerability and correlates strongly with IVUS-derived necrotic core in patients with ACS.

Cite This Study

Benedek et al. (2014) studied this question.

synapsesocial.com/papers/6a7d31b11b8ecc4e56964affhttps://doi.org/10.1536/ihj.13-213
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