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July 15, 2015CNS Neuroscience & TherapeuticsOpen Access

CYP2C19*2 and CYP2C19*3 alleles were significantly associated with high on-clopidogrel platelet reactivity (P < 0.001 and P = 0.001, respectively), but not with clinical outcomes (P > 0.05), whereas high platelet reactivity was significantly associated with ischemic events (P = 0.001).

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Why the study?

Do genetic polymorphisms (CYP2C19) influence platelet reactivity and ischemic events in patients with acute ischemic stroke treated with clopidogrel?

Population

345 patients hospitalized in Changhai Hospital (China) with acute ischemic stroke

Design

Cohort, randomly enrolled

Follow-up

1 year

Authors

YHYan HanHLH.‐J. LvXLXu Liu

Discussion

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Overview

High on-clopidogrel reactivity signals ischemic risk in stroke; supports reactivity testing but leaves CYP2C19 genotyping utility open.

Structured PICO

Do genetic polymorphisms (CYP2C19) influence platelet reactivity and ischemic events in patients with acute ischemic stroke treated with clopidogrel?

P
Population
345 patients hospitalized in Changhai Hospital (China) with acute ischemic stroke
I
Intervention
Clopidogrel 75 mg daily maintenance dose
O
Outcome
Ischemic events, including major adverse cardiac events (MACE), recurrence of stroke, transient ischemic attack (TIA), and the composite of vascular deathcomposite

High on-clopidogrel platelet reactivity, influenced by CYP2C19*2 and *3 alleles, is an independent risk factor for ischemic events in acute ischemic stroke patients.

Cite This Study

Han et al. (2015) studied this question.

synapsesocial.com/papers/6a7d31f7166e996abdd5a666https://doi.org/10.1111/cns.12426
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China2013 · 105 citations
  2. 2Clopidogrel responder status is uninfluenced by CYP2C19*2 in Danish patients with stroke2020 · 5 citations
  3. 3Association of &lt;i&gt;CYP2C19&lt;/i&gt; Polymorphisms With Clopidogrel Reactivity and Clinical Outcomes in Chronic Ischemic Stroke2019 · 29 citations
  4. 4Analysis of CYP2C19 gene polymorphism and influencing factors of pharmacological response of clopidogrel in patients with cerebral infarction in Zhejiang, China2023 · 3 citations
  5. 5Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke2016 · 56 citations