Why the study?
Sex differences in acute coronary syndrome outcomes persist despite major advances in cardiovascular care, with women experiencing worse short- and long-term outcomes than men.
Persistent sex disparities in acute coronary syndrome outcomes underscore the need for sex-informed research, equitable care delivery, and tailored risk prediction tools.
ACS outcomes remain worse in women; confirms need for sex-specific strategies in care and trials.
Acute coronary syndrome (ACS) remains a global health challenge, with sex differences in outcomes persisting despite major advances in cardiovascular care. Women continue to experience worse short- and long-term outcomes than men, including higher mortality, complications, and hospital readmissions - particularly among younger women. These disparities reflect biological, psychosocial, and healthcare system factors, including delayed diagnosis and lower access to guideline-based interventions. Evidence from low- and middle-income countries, though limited, suggests similar or greater disparities. Most available data are from observational studies, with randomized trials rarely designed to assess sex-specific effects. Addressing these gaps requires sex-informed research, equitable care delivery, and risk prediction tools tailored by sex to improve ACS outcomes globally.
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Kunutsor et al. (2025) studied this question.
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