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July 1, 1988CirculationOpen Access

Long-term prognosis for patients with variant angina and influential factors.

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Why the study?

What is the long-term prognosis for patients with variant angina, and does the use of calcium antagonists improve survival without myocardial infarction?

Population

245 patients with variant angina

Design

Cohort

Follow-up

average 80.5 months (range, 36-184 months)

Authors

HYHirofumi YasueATAkinori TakizawaMNMichinobu Nagao

Discussion

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Overview

Supports favorable long-term prognosis in variant angina; leaves open whether calcium antagonists improve MI-free survival.

Key Points

  • To assess long-term survival and identify clinical factors determining outcomes and myocardial infarction risk in patients with variant angina.
  • Followed 245 patients with variant angina for a mean duration of 80.5 months (range, 36–184 months).
  • Evaluated clinical, electrocardiographic, and angiographic determinants of overall survival and myocardial infarction-free survival using univariate tests and multivariate Cox proportional hazards models.
  • Overall survival rates were 98% at 1 year, 97% at 3 and 5 years, and 93% at 10 years.
  • Infarction-free survival rates were 86% at 1 year, 85% at 3 years, 83% at 5 years, and 81% at 10 years.
  • Multivariate Cox modeling identified calcium antagonist use, extent and severity of coronary artery disease, and concurrent ST segment elevation in both anterior and inferior leads as significant independent predictors of infarction-free survival.

Structured PICO

What is the long-term prognosis for patients with variant angina, and does the use of calcium antagonists improve survival without myocardial infarction?

P
Population
245 patients with variant angina
I
Intervention
Calcium antagonists
O
Outcome
Survival rate and survival rate without myocardial infarctionhard clinical

The long-term prognosis for patients with variant angina is relatively good, and the use of calcium antagonists is an independent predictor of improved survival without myocardial infarction.

Cite This Study

Yasue et al. (1988) studied this question.

synapsesocial.com/papers/6a7d3276f1daba58ecd5ab73https://doi.org/10.1161/01.cir.78.1.1
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