What question did this study set out to answer?

To establish and demonstrate two surgical routes for delivering antisense oligonucleotides directly into the mouse cerebral ventricles to bypass the blood-brain barrier.

May 9, 2013Journal of Visualized Experiments

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

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To establish and demonstrate two surgical routes for delivering antisense oligonucleotides directly into the mouse cerebral ventricles to bypass the blood-brain barrier.
Surgical implantation of an intracerebroventricular catheter connected to a subcutaneous Alzet osmotic pump for continuous drug infusion into the lateral ventricle.
Direct stereotaxic microinjection of a single high-concentration bolus directly into the right lateral ventricle.
Both delivery routes successfully distribute therapeutic compounds through the cerebral ventricular network to reach the entire brain and spinal cord.
Continuous infusion provides sustained drug exposure over designated timeframes, while bolus injection enables rapid administration depending on experimental objectives.

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Implication

Preclinical protocol demonstrates continuous infusion and bolus intraventricular drug delivery in mice, highlighting viable strategies to bypass the blood-brain barrier.

Cite This Study

DeVos et al. (2013) studied this question.

synapsesocial.com/papers/6a7d3618fac401f2784258f3 https://doi.org/10.3791/50326

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Implication

Preclinical protocol demonstrates continuous infusion and bolus intraventricular drug delivery in mice, highlighting viable strategies to bypass the blood-brain barrier.

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Key Points

Discussion

Implication

Cite This Study

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Key Points

Discussion

Implication

Cite This Study

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