A Methicillin-Resistant Strain of Staphylococcus aureus

Article1 July 1967A Methicillin-Resistant Strain of Staphylococcus aureusClinical and Laboratory ExperienceROGER J. BULGER, M.D.ROGER J. BULGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-81 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the United States there has been only one well-documented case of serious infection caused by methicillin-resistant Staphylococcus aureus (1). Most of the clinical reports have come from Paris where Chabbert, Baudens, Acar, and Gerband (2) have found a higher mortality in patients infected with methicillin-resistant strains than with methicillin-sensitive multiple-resistant staphylococci (2).In England a great deal of laboratory and epidemiologic data have been published, but little clinical information has been included (3-7). Laboratory surveys in the United States have generally failed to turn up significant methicillin resistance (8).In September 1965 two patients on the same ward in...References1. DOWLING HF: The newer penicillins. Clin. Pharmacol. Ther. 2: 572, 1961. CrossrefMedlineGoogle Scholar2. CHABBERTBAUDENSACARGERBAND YAJGJFGR: La resistance naturelle des Staphylocoques a la methicilline et l'oxacilline (abstract). Rev. Franc. Etud. Clin. Biol. 10: 495, 1965. MedlineGoogle Scholar3. BARBER M: Naturally occurring methicillin-resistant staphylococci. J. Gen. Microbiol. 35: 183, 1964. CrossrefMedlineGoogle Scholar4. JEVONSCOEPARKER MPAWMT: Methicillin resistance in staphylococci. Lancet 1: 904, 1963. CrossrefMedlineGoogle Scholar5. STEWARTHOLT GTRJ: Evolution of natural resistance to the newer penicillins. Brit. Med. J. 1: 308, 1963. CrossrefMedlineGoogle Scholar6. SUTHERLANDROLINSON RGN: Characteristics of methicillin-resistant staphylococci. J. Bact. 87: 887, 1964. CrossrefMedlineGoogle Scholar7. DYKEJEVONSPARKER KGMPMT: Penicillinase production and intrinsic resistance to penicillins in Staphylococcus aureus. Lancet 1: 835, 1966. CrossrefMedlineGoogle Scholar8. GRAVENKEMPERBRODIEKIRBY CFJLWM: Resistance of coagulase-positive staphylococci to methicillin and oxacillin. J. Bad. 89: 1005, 1965. CrossrefMedlineGoogle Scholar9. BULGERBULGER RJRE: Unpublished observations. Google Scholar10. BENNETTBRODIEBENNERKIRBY JVJLEJWM: Simplified accurate method for antibiotic assay of clinical specimens. Appl. Microbiol. 14: 170, 1966. CrossrefMedlineGoogle Scholar11. ERICKSENERICKSEN KRI: Inactivation of methicillin, oxacillin, cloxacillin and cephalothin by staphylococcal penicillinase. Acta Path. Microbiol. Scand. 62: 399, 1964. CrossrefMedlineGoogle Scholar12. HASHIMOTOKONOMITSUHASHI HKS: Elimination of penicillin resistance of Staphylococcus aureus by treatment with acriflavine. J. Bact. 88: 261, 1964. CrossrefMedlineGoogle Scholar13. GOTS JS: The detection of penicillinase-producing properties of micro-organisms. Science 102: 309, 1945. CrossrefMedlineGoogle Scholar14. ERICKSENERICKSEN KRI: Resistance to methicillin, isoxazolyl penicillins and cephalothin in Staphylococcus aureus. Acta Path. Microbiol. Scand. 62: 255, 1964. CrossrefMedlineGoogle Scholar15. SELIGMAN S: Penicillinase-negative variants of methicillin-resistant Staphylococcus aureus. Nature (London) 09: 994, 1966. CrossrefGoogle Scholar16. WISESPINK RIWW: The influence of antibiotic on the origin of small colonies (G variants) of micrococcus pyogenes var. aureus. J. Clin. Invest. 33: 1611, 1954. CrossrefMedlineGoogle Scholar17. BULGER RJ: In vitro studies of the antibacterial activity of cephalothin-kanamycin and methicillin-kanamycin combinations with methicillin-resistant strains of Staphylococcus aureus. Lancet 1: 17, 1967. CrossrefMedlineGoogle Scholar18. SMITHARMOUR DHSE: Transferable R factors in enteric bacteria causing infection of the genitourinary tract. Lancet 2: 15, 1966. CrossrefMedlineGoogle Scholar19. Editorial: Infectious drug resistance. New Eng. J. Med. 275: 277, 1966. CrossrefMedlineGoogle Scholar20. BARBERDUTTONBEARDELMESWILLIAMS MAAMAPCR: Reversal of antibiotic resistance in hospital staphylococcal infection. Brit. Med. J. 1: 11, 1960. CrossrefMedlineGoogle Scholar21. GILLHOOK FAEW: Changing patterns of bacterial resistance to antimicrobial drugs. Amer. J. Med. 39: 780, 1965. CrossrefMedlineGoogle Scholar22. BAUERKIRBYSHERRISTURCK AWWMJCM: Antibiotic susceptibility testing by a standardized single disk method. Amer, J. Clin. Path. 45: 493, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER J. BULGER, M.D.Affiliations: Seattle, WashingtonFrom the Department of Medicine, the University of Washington School of Medicine, and the Veterans Administration Hospital, Seattle, Wash.This study was supported by grant AI 169-05, the U. S. Public Health Service, Washington, D. C.This work was done while Dr. Bulger was a U. S. Public Health Service Trainee in Clinical Microbiology and subsequently a Clinical Investigator, U. S. Veterans Administration.Requests for reprints should be addressed to Roger J. Bulger, M.D., c/o University Hospital, 1959 Pacific Ave., Seattle, Wash. 98105. 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BULGER, M.D., JOHN C. SHERRIS, M.D.Methicillin-Resistant Staphylococcus aureus at Boston City HospitalInfectious diseases. Annual review of significant publications.Staphylococcal infections—Treatment and controlMethicillin-Resistant Staphylococci 1 July 1967Volume 67, Issue 1Page: 81-89KeywordsClinical epidemiologyClinical microbiologyHospital medicineMedical servicesMethicillin-resistant staphylococcus aureusMicrobiologyMortalityResearch laboratoriesStaphylococcal infectionStaphylococcus aureus ePublished: 1 December 2008 Issue Published: 1 July 1967 PDF downloadLoading ...