Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke
Why the study?
Does clopidogrel plus aspirin improve functional outcome in patients with acute minor stroke or TIA?
Population
Patients with acute minor stroke or TIA from the CHANCE trial
Comparison
Clopidogrel plus aspirin vs Aspirin alone
Design
RCT
Follow-up
90 days
Authors
Discussion
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Member takes
Implication
Supports dual antiplatelet therapy in minor stroke or TIA; confirms improved 90-day functional outcomes versus aspirin alone.
Structured PICO
Does clopidogrel plus aspirin improve functional outcome in patients with acute minor stroke or TIA?
P
Population
Patients with acute minor stroke or TIA from the CHANCE trial
I
Intervention
Clopidogrel plus aspirin
C
Comparator
Aspirin alone
O
Outcome
Poor functional outcome (modified Rankin Scale score of 2-6) at 90 dayspatient reported
In patients with minor stroke or TIA, dual antiplatelet therapy with clopidogrel and aspirin improves 90-day functional outcome compared to aspirin alone.
Cite This Study
Wang et al. (2015) studied this question.