Why the study?
Giant cell myocarditis is rapidly progressive and potentially fatal, but detailed inflammatory responses remain unknown, particularly the formation of multinucleate giant cells.
Does inhibition of NETosis via PAD4 alleviate inflammation in giant cell myocarditis?
Population
15,714 Cd45+ cells from GCM and normal rats, plus patients with GCM, DCM, and healthy controls
Comparison
Inhibition of NETosis with GSK484 vs untreated, and GCM patients vs DCM patients and healthy controls
Design
Preclinical animal and translational human study
Authors
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NETosis inhibition may offer a novel GCM therapy; leaves open confirmation in human disease.
Does inhibition of NETosis via PAD4 alleviate inflammation in giant cell myocarditis?
Inhibition of NETosis via PAD4 may serve as a potential therapeutic target for alleviating inflammation in giant cell myocarditis.
Zhan et al. (2023) studied this question.
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